Diabetes Reduces Phosphorylation in Human Retina of αA-crystallin on T148, a Site Regulating its Protective Function in Neurons and Glia
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چکیده
These abstracts are licensed under a Creative Commons Attribution-NonCommercial-No Derivatives 4.0 International License. Go to http://iovs.arvojournals.org/ to access the versions of record. 506 Diabetic Retinopathy: Neurodegeneration and pathology associated with the neurovascular unit. Thursday, May 11, 2017 8:30 AM–10:15 AM Exhibit/Poster Hall Poster Session Program #/Board # Range: 5189–5205/B0076–B0092 Organizing Section: Retinal Cell Biology
منابع مشابه
A specific phosphorylation regulates the protective role of αA-crystallin in diabetes.
Neurodegeneration is a central aspect of the early stages of diabetic retinopathy, the primary ocular complication associated with diabetes. While progress has been made to improve the vascular perturbations associated with diabetic retinopathy, there are still no treatment options to counteract the neuroretinal degeneration associated with diabetes. Our previous work suggested that the molecul...
متن کاملIncreased expression of αA-crystallin in human diabetic eye.
We recently demonstrated that αA-crystallin, a molecular chaperone, protected photoreceptors from apoptotic signals in intraocular inflammation. Advanced glycation end product (AGE) plays an important role in the progression of diabetic retinopathy. The aim of this study was to examine the expression of α-crystallins and apoptosis in human diabetic retina, and to analyze α-crystallin up-regulat...
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Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
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Most neurons in the adult mammalian brain survive for the entire life of an individual. However, it is not known which transcriptional pathways regulate this survival in a healthy brain. Here, we identify a pathway regulating neuronal survival in a highly subtype-specific manner. We show that the transcription factor Pax6 expressed in dopaminergic neurons of the olfactory bulb regulates the sur...
متن کاملThe role of glia in neurological disease
Glial cells form a network in the central nervous system to support neurons and interact with them. The glia consist essentially of astrocytes that help with the nutrition of neurons and react in some cases of injury, oligodendrocytes that produce myelin, and microglia that are derived from the haemopoietic system and are concerned with the immunological defense of the nervous system. Experimen...
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تاریخ انتشار 2017